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El gran ENGAÑO de la L-CARNITINA

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Flecha Verde El gran ENGAÑO de la L-CARNITINA
por Toni 31-08-2011

Comentar que hasta hace poco era usuario de L-Carnitina y pensaba que me ayudaba a quemar grasas, pero visto lo visto tendré que rendirme a la evidencia y olvidarme de este suplemento.

Por mi parte la L-Carnitina pasa a ser un suplemento más que irá a parar al gran baúl de los suplementos que no valen para nada pero que la industria de la suplementación totalmente carente de ética y moral nos sigue vendiendo con falsas promesas sin ninguna base cientifica solida que respalde sus supuestos beneficios.

1)Un estudio llamado "Effect of L-carnitine on weight loss and body compositi on of rats fed a hypocaloric diet", llevado a cabo por el Institute of Nutrition al Sciences, Universit y of Halle, Germany, administró L-Carnitina a ratas con unos 2.5 gr durante una dieta hipocalórica. La conclusión: la carnitina no mejoró ningún parámetro y la carnitina endógena era suficiente para asegurar la beta oxidación durante una fase catabólica.

Effect of L-carnitine on weight loss and body... [Ann Nutr Metab. 2002] - PubMed - NCBI
Cita:
Effect of L-carnitine on weight loss and body composition of rats fed a hypocaloric diet.
Brandsch C, Eder K.
Source

Institute of Nutritional Sciences, University of Halle, Germany.
Abstract
BACKGROUND/AIMS:

Several studies have been published in recent years which suggest that L-carnitine supplementation can influence the lipid metabolism in some species and can also affect body composition of growing animals. Only few results are available so far on the effect of L-carnitine supplementation on weight reduction and body composition of animals fed an energy-deficient diet. The aim of this study was therefore to investigate whether L-carnitine supplementation combined with an energy-deficient diet can influence weight development and body composition.
METHODS:

An experiment was conducted with 36 rats with an initial body weight of about 460 g. One-third of the rats were killed, the remainder were divided into two groups (control group, treated group) and fed a semi synthetic diet at an energy level of about half of the rats' maintenance requirement. The basal diet was essentially carnitine-free. The diet of the treated group was supplemented with L-carnitine (5 g/kg). The feeding period extended over 23 days. Experimental parameters were weight loss, composition of carcass and weights of the fat pads surrounding the kidneys, intestine and testes; several clinico-chemical plasma parameters were also determined.
RESULTS:

As was to be expected, the rats lost a considerable amount of weight on the energy-reduced diet. At the same time a shift occurred in the ratio of fat to protein in favour of protein in the carcass, leading to a marked reduction of body fat levels and a slight reduction of protein levels. There were, however, no significant differences between the control group and the treated group (with L-carnitine supplementation) with regard to any of these parameters. The clinico-chemical parameters measured in plasma (glucose, triglycerides, total cholesterol, free fatty acids, 3-hydroxybutyric acid) also showed no differences between the groups.
CONCLUSIONS:

The rat model used here did not show a positive effect of L-carnitine supplementation on weight loss and body composition of rats fed an energy-deficient diet. The animals' endogenous carnitine synthesis was obviously adequate to ensure efficient beta-oxidation of fatty acids during the catabolic phase.

Copyright 2002 S. Karger AG, Basel
PMID: 12378044 [PubMed - indexed for MEDLINE]
2) Otro estudio llamado "L-carnitine supplemen tation does not promote weight loss in ovariectomized rats despite endurance exercise" fue realizado por el Department of Kinesiology, School of Health Sciences, West Chester University, concluye que la suplementación con carnitina no redujo la ganancia de peso ni la grasa abdominal en ratones gordos femeninos adultos. Y ahora lo mejor: las ratas que consumieron carnitina ganaron peso.

L-carnitine supplementation does not pr... [Int J Vitam Nutr Res. 2005] - PubMed - NCBI
Cita:
L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.
Melton SA, Keenan MJ, Stanciu CE, Hegsted M, Zablah-Pimentel EM, O'Neil CE, Gaynor P, Schaffhauser A, Owen K, Prisby RD, LaMotte LL, Fernandez JM.
Source

Department of Kinesiology, School of Health Sciences, West Chester University, West Chester, PA 19383, USA. smelton@wcupa.edu
Abstract

In this five-week study, we tested the hypotheses that free access to a maintenance diet supplemented with L-carnitine (L-C) would reduce body fat in adult, sedentary, ovariectomized (OVX) rats, and that there would be an additive effect of L-C on weight reduction in swim-trained animals. As expected, serum carnitine was higher in rats fed the L-C diet, and the OVX-induced weight gain and abdominal fat were counteracted by swimming. L-C supplementation did not reduce the weight gain or abdominal fat in these adult female rats, Moreover, though not reaching statistical significance, rats that were fed L-C demonstrated a tendency for greater weight gain than their basal-fed counterparts despite no difference in energy intake. If the results of this study on ovariectomized rats can be translated to postmenopausal women, moderate intensity exercise may be recommended, but L-C supplementation, with no energy restriction, may be contraindicated as a weight loss method in this cohort.
PMID: 15929637 [PubMed - indexed for MEDLINE]
3) El Institute of Biomedical Sciences, USP, São Paulo, Brazil, no contentos con quitarnos las olimpiadas, quisieron destrozar el mito de la L-Carnitina para perder peso. Y vaya si lo hicieron: en ratas entrenadas para el ejercicio aeróbico, la carnitina no sirvió para nada comparada con el grupo de control que no tomó el suplemento.

4) Otro estudio llamado "L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderatel y obese women" fue llevado a cabo por el Department of Human Biology and Movement Science, Royal Melbourne Institute of Technolog y, Australia . Administró carnitina a 36 mujeres durante 8 semanas. 5 experimentaron náusea y/o diarrea, y además, la L-Carnitina se mostró totalment e ineficaz para perder peso.

L-Carnitine supplementation com... [Int J Sport Nutr Exerc Metab. 2000] - PubMed - NCBI
Cita:
L-Carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.
Villani RG, Gannon J, Self M, Rich PA.
Source

Department of Human Biology and Movement Science, Royal Melbourne Institute of Technology, Melbourne, Victoria, 3083, Australia.
Abstract

L-Carnitine (L-C) transports fatty acids into mitochondria for oxidation and is marketed as a weight loss supplement. In a double-blind investigation to test the weight loss efficacy of L-C, 36 moderately overweight premenopausal women were pair matched on Body Mass Index (BMI) and randomly assigned to two groups (N = 18). For 8 weeks the L-C group ingested 2 g twice daily of L-C, while the placebo (P) group ingested the same amount of lactose. All subjects walked for 30 min (60-70% maximum heart rate) 4 days/week. Body composition, resting energy expenditure (REE) and substrate utilization were estimated before and after treatment. For the subjects who completed the study (15 P, 13 L-C), no significant changes in mean total body mass (TBM), fat mass FM, and resting lipid utilization occurred over time, nor were there any significant differences between groups for any variable. Conversely REE increased significantly for all subjects, but no between group differences existed. Five of the L-C group experienced nausea or diarrhea and consequently did not complete the study. Eight weeks of L-C ingestion and walking did not significantly alter the TBM or FM of overweight women, thereby casting doubt on the efficacy of L-C supplementation for weight loss.
PMID: 10861338 [PubMed - indexed for MEDLINE]
5) Otro estudio en mujeres premenopá usicas no encontró efectividad en la suplementación. "Weight loss associated with reduced intake of carbohydrate reduces the atherogen icity of LDL in premenopausal women"

Weight loss associated with reduced intake of car... [Metabolism. 2005] - PubMed - NCBI
Cita:
Weight loss associated with reduced intake of carbohydrate reduces the atherogenicity of LDL in premenopausal women.
Lofgren I, Zern T, Herron K, West K, Sharman MJ, Volek JS, Shachter NS, Koo SI, Fernandez ML.
Source

Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
Abstract

The effect of a 3-tier intervention including dietary modifications (ie, moderate energy restriction, decreased carbohydrate, increased protein), increased physical activity, and the use of carnitine as a dietary supplement was evaluated on plasma lipids and the atherogenicity of low-density lipoprotein (LDL) particles in a population of overweight and obese premenopausal (aged 20-45 years) women. Carnitine or a placebo (cellulose) was randomly assigned to the participants using a double-blind design. Carnitine supplementation was postulated to enhance fat oxidation resulting in lower concentrations of plasma triglycerides. Seventy women completed the 10-week protocol, which followed a reduction in their energy intake by 15% and a macronutrient energy distribution of 30% protein, 30% fat, and 40% carbohydrate. In addition, subjects increased the number of steps taken per day by 4500. As no differences were observed between the carnitine and placebo groups in all the measured parameters, all subjects were pooled together for statistical analysis. Participants decreased (P<.01) their caloric intake (between 4132.8 and 7770 kJ) and followed prescribed dietary modifications as assessed by dietary records. The average number of steps increased from 8950+/-3432 to 12764+/-4642 (P<.001). Body weight, plasma total cholesterol, LDL cholesterol, and triglyceride were decreased by 4.5%, 8.0%, 12.3%, and 19.2% (P<.0001), respectively, after the intervention. Likewise, apolipoproteins B and E decreased by 4.5% and 15% (P<.05) after 10 weeks. The LDL mean particle size was increased from 26.74 to 26.86 nm (P<.01), and the percent of the smaller LDL subfraction (P<.05) was decreased by 26.5% (P<.05) after 10 weeks. In addition, LDL lag time increased by 9.3% (P<.01), and LDL conjugated diene formation decreased by 23% (P<.01), indicating that the susceptibility of LDL to oxidation was decreased after the intervention. This study suggests that moderate weight loss (<5% of body weight) associated with reduced caloric intake, lower dietary carbohydrate, and increased physical activity impacts the atherogenicity of LDL.
PMID: 16125523 [PubMed - indexed for MEDLINE]
6) Otro estudio doble ciego durante 26 semanas administrando 2gr diarios a diabéticos no encontró ningún efecto. "The Effect of L-carnitine on plasma lipoprote in(a) Levels in Hyperchol esterolem ic Patients with Type 2 Diabetes Mellitus"

The effect of L-carnitine on plasma lipoprotein(a)... [Clin Ther. 2003] - PubMed - NCBI
Cita:
The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus.
Derosa G, Cicero AF, Gaddi A, Mugellini A, Ciccarelli L, Fogari R.
Source

Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. giuderosa@tin.it
Abstract
BACKGROUND:

A previous study has demonstrated that L-carnitine reduces plasma lipoprotein(a) (Lp[a]) levels in patients with hypercholesterolemia.
OBJECTIVE:

To test a tolerable Lp(a)-reducing agent in diabetic patients, we assessed the effect of a dietary supplementation of L-carnitine on plasma lipid levels, particularly Lp(a), of patients with type 2 diabetes mellitus (DM) and hypercholesterolemia.
METHODS:

In this 6-month, randomized, double-masked, placebo-controlled clinical trial, patients were enrolled, assessed, and followed up at the Diabetic and Metabolic Diseases Center of the Department of Internal Medicine and Therapeutics at the University of Pavia, Pavia, Italy. All study patients had newly diagnosed type 2 DM that was managed through dietary restriction alone throughout the study, as well as hypercholesterolemia. Patients were randomized to 1 of 2 groups. One group received L-carnitine, one 1-g tablet BID. The other group received a corresponding placebo. We assessed body mass index, fasting plasma glucose, postprandial plasma glucose, glycosylated hemoglobin, fasting plasma insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein (apo) A-I, apo B, and Lp(a) at baseline and at 1, 3, and 6 months of treatment.
RESULTS:

This study included 94 patients. The treatment group included 24 men and 22 women (mean [SD] age, 52 [6] years). The placebo group included 23 men and 25 women (mean [SD] age, 50 [7] years). The baseline characteristics of the groups did not differ significantly. The mean (SD) body weight, height, and body mass index were 78.2 (5.8) kg, 1.70 (0.04) m, and 27.3 (2.5) kg/m(2), respectively, in the L-carnitine group and 77.6 (6.4) kg, 1.71 (0.05) m, and 26.8 (2.2) kg/m(2), respectively, in the placebo group. In the treatment group, Lp(a) was significantly reduced at 3 and 6 months compared with baseline (P < 0.05) and P < 0.01, respectively). We observed a significant improvement after 6 months (P < 0.05) in the Lp(a) value in patients taking L-carnitine compared with those taking placebo. Between-group differences in other variables did not reach a level of significance at months 3 and 6. No drug-related adverse events were reported or observed.
CONCLUSION:

In this preliminary study, after 3 and 6 months, L-carnitine significantly lowered the plasma Lp(a) level compared with placebo in selected hypercholesterolemic patients with newly diagnosed type 2 DM.
PMID: 12867219 [PubMed - indexed for MEDLINE]
7) Otro estudio en bipolares con sobrepeso asociado a la medicación, administr ó L-Carnitina durante 26 semanas. Se llamó "Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet" El título lo dice todo: absolutamente ineficaz.

Carnitine does not improve weight loss outcom... [Bipolar Disord. 2006] - PubMed - NCBI
Cita:
Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet.
Elmslie JL, Porter RJ, Joyce PR, Hunt PJ, Mann JI.
Source

Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand. jane.elmslie@chmeds.ac.nz
Abstract
OBJECTIVES:

Carnitine deficiency impairs fatty acid beta-oxidation and may partly explain weight gain in valproate-treated patients. The aim of this study was to determine whether l-carnitine supplementation improves weight loss outcomes in bipolar patients taking sodium valproate.
METHODS:

Sixty bipolar patients with clinically significant weight gain thought to be related to sodium valproate, who had been taking sodium valproate for >or=6 months, were randomized to l-carnitine (15 mg/kg/day) or placebo for 26 weeks, in conjunction with a moderately energy-restricted, low-fat diet. The primary outcome measure was weight change.
RESULTS:

l-carnitine had no effect on mean weight loss compared with placebo (-1.9 kg versus - 0.9 kg) (F = 0.778, df = 1,58, p = 0.381). The number of people in each group able to lose any weight was identical ( = 0, p = 1.0); more patients in the carnitine group (nine versus five) achieved a clinically significant weight loss (>or=5%) but this was not statistically significant (p = 1.0, Fisher's exact test).
CONCLUSIONS:

At the dose prescribed in this study carnitine supplementation did not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet.
PMID: 17042889 [PubMed - indexed for MEDLINE]

Se puede encontrar un estudio que si encontró reducción de peso. El problema es que el estudio recibió una valoració n de 1 sobre 5 (peor valoració n posible) en la escala de Jadad, que mide la calidad de los ensayos clínicos. Es decir: ni randomiza do, ni doble ciego, ni explica el seguimien to… Un estudio con menos de 3 no se suele aceptar para posterior es inclusion es científic as. Asi que una auténtica chapuza. Pero para que no se diga, aquí lo dejo: "Carnitine, Choline Supplemen tation with Exercise Alter Carnitine Profiles, Biochemic al Markers of Fat Metabolis m and Serum Leptin Concentra tion in Healthy Women"
http://jn.nutrition.org/content/133/1/84.short

Despues de esto yo ya lo tengo claro...
a partir de ahí cada cual decide en que gasta su dinero

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  #2  
Antiguo 31-08-2011, 12:14 PM
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nirvanarosa is an unknown quantity at this point
Predeterminado L-Carnitina OH!

Vaya! Que sorpresa respecto a la L-Carnitina. Yo le tenía fe.
Mas bien, ya me queda solo dosis para 4 días...
Trataré de investigar un poco porque me has dejado pensando mucho al respecto. Ya no se si seguir consumiendo o no...
Ya te contaré si encuentro algo.
Un saludo
__________________

Yo sigo el Metodo Gabriel y funciona :yahoo:

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  #3  
Antiguo 31-08-2011, 01:05 PM
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Quemando Grasa xDDDDDDD
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Predeterminado

Yo era un defensor de este suple, pero visto lo visto nunca mais...
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  #4  
Antiguo 31-08-2011, 09:49 PM
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Predeterminado

Yo hace ya tiempo que dejé de usarla, además después de leer algunos artículos y estudios del estilo que has puesto, se me ocurrió comentar en un foro que se podía considerar como un simple placebo, y me dijeron de todo...desde entonces prefiero no opinar sobre este suplemento, como tu dices Toni, que cada cual gaste su dinero en lo que le de la gana, porque donde vayas te vas a encontrar a ferreos defensores que te dirán que no tienes ni puta idea, y otros que los efectos son nulos o inapreciables.

Hay muchos profesionales que te dicen que para tomar carnitina, mejor cuando quieras definir comprar un buen termogenico tipo Hydroxycut, Lipo6Black o Animal cuts, pero otros lo siguen defendiendo a capa y espada.

Yo, personalmente, he de decir que durante un mes tomando todos los días y otro sin tomar nada, y con exactamente el mismo entrenamiento y la misma dieta, he conseguido EXACTAMENTE los mismos resultados.
__________________

Descarga el Metodo Gabriel

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  #5  
Antiguo 31-08-2011, 10:20 PM
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Yo pensaba que si que funcionaba y hace nada me hice con dos cajas de carnicor que ya mehe terminado.
Que desengaño, ya no compro mas esto en la vida

Cita:
Yo, personalmente, he de decir que durante un mes tomando todos los días y otro sin tomar nada, y con exactamente el mismo entrenamiento y la misma dieta, he conseguido EXACTAMENTE los mismos resultados.
Es que eso es lo que más hace y funciona seguro al 100%

de todas maneras me he comprado unos BCAAs de USP labs que se supone que son buenos, a ver si noto mas recuperacion con ellos. Tambien se supone que pueden servir para proteger al musculo en una definición más extrema, a ver si es verdad y noto algo con ellos, pero tampoco tengo mucha fe : S
__________________

Ya son 12Kg. menos con el Metodo Gabriel :)

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  #6  
Antiguo 09-09-2011, 01:35 AM
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Chusco is an unknown quantity at this point
Predeterminado

Parece mentira de como las casas comerciales, nos llevan a todos por el camno que les interesa. Menos mal que leyendo, buscando y escuchando a los que saben llegas a darte cuenta de que eto es un gran negocio, todos queremos estar estupendos de la muerte con el menor sacrificio, pero eso no pasa. ¿Por qué hay medicos gordos? ¿Por qué hay medicos calvos? Se cuponen que ellos son los que más saben ¿NOOO? No existen los milagros; EXISTE L ESFUERZO Y EL AFAN DE SUPERACIÓN.

Gracias amigos por ayudarnos a ver la realidad.
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